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pentobarbital will lessen the extent or effect of brexpiprazole by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Check Intently. Double brexpiprazole dose over 1-two weeks if administered with a robust CYP3A4 inducer.pentobarbital will lessen the extent or effect of conjugated estrogens by influencing hepatic/intestinal enzy